We are developing novel drugs to treat heart failure

AnaCardio AB is a privately held Swedish, clinical stage biopharmaceutical company developing novel drugs to treat heart failure. Our mission is to make the heart stronger safely.

Heart Failure – A global public health problem

Heart failure (HF) affects more than six million individuals in the US and nearly 100 million worldwide, causing poor quality of life, recurrent hospitalizations, and a high risk of death. HF is a progressive cardiac syndrome, and it impairs ventricles’ ability to fill with or eject blood. The most common and serious form is HF with reduced ejection fraction, where contractility is reduced, leading to impaired delivery of blood and oxygen to organs and tissues.

Unmet needs

Current chronic heart failure treatment does not target the underlying cause

Existing oral therapy delays progression and reduces hospitalization and death but no treatment targets impaired contractility – the underlying cause

Huge unmet need in acute/advanced heart failure‍

Intravenous “inotropes” increase cardiac output to maintain organ function for hours-days, but cause ischemia, arrhythmia, hypotension, and increased mortality

Heart failure patients are currently underserved and no existing treatment:

  • Effectively and safely improves contractility
  • Increases contractility without increasing O2 consumption or mortality
  • Is effective in chronic, acute and advanced heart failure

Proof-of-concept for a novel mode-of-action

AnaCardio is developing novel inotropic agents with a unique mode-of-action based on the ghrelin signalling pathway, intended to increase contractility without causing adverse tachycardia, arrhythmia, ischemia, or hypotension. The agents increase cardiomyocyte contractility and force, leading to increased cardiac output which can potentially improve organ function, quality of life and functional capacity, and reduce the risk of hospitalization and death. 

Latest news

Key investors

Selected company for:

Contact us

Get in touch

Feel free to contact us if you have any questions or want to book a meeting.