AnaCardio AB is a privately held Swedish, clinical stage biopharmaceutical company developing novel drugs to treat heart failure. Our mission is to make the heart stronger safely.
Heart failure (HF) affects more than six million individuals in the US and nearly 100 million worldwide, causing poor quality of life, recurrent hospitalizations, and a high risk of death. HF is a progressive cardiac syndrome, and it impairs ventricles’ ability to fill with or eject blood. The most common and serious form is HF with reduced ejection fraction, where contractility is reduced, leading to impaired delivery of blood and oxygen to organs and tissues.
Existing oral therapy delays progression and reduces hospitalization and death but no treatment targets impaired contractility – the underlying cause
Intravenous “inotropes” increase cardiac output to maintain organ function for hours-days, but cause ischemia, arrhythmia, hypotension, and increased mortality
AnaCardio is developing novel inotropic agents with a unique mode-of-action based on the ghrelin signalling pathway, intended to increase contractility without causing adverse tachycardia, arrhythmia, ischemia, or hypotension. The agents increase cardiomyocyte contractility and force, leading to increased cardiac output which can potentially improve organ function, quality of life and functional capacity, and reduce the risk of hospitalization and death.
Solna, Sweden and Lugano, Switzerland, April 13, 2022 AnaCardio, a Swedish clinical-stage biopharmaceutical company focussed on developing novel contractile agents with a unique mode of-action
Stockholm, Sweden, March 14 , 2023 AnaCardio´s founder Prof Lars Lund and colleagues from The Karolinska Institutet publish study on ghrelin treatment in patients with
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